To your point about strokes. Imitrex can cause a stroke if you take too many shots/pills a month. I can get up to 25 migraines, and finally started using Aimovig as a prophylactic. I was heading for a stroke as the Imitrex is a vaso constrictor. The Aimovig works. As with all things, I have tried them for more than forty years. This works. Other meds had awful and debilitating side effects. The jury is still out on this one. We really do not understand this stuff, and because it relegated to women, not that important. Well. That is until the doctor starts getting them, that is.