Thanks, Timo. The issue of gut biome, which also expands into the entire complex discussion of how our gut is the second brain as well as the swiftly expanding but still little understood aspects of hormonal changes which occur around menopause for women is still a growing field. It is quite impossible to cover all of it in any one article, so we have to choose a lane, expand that point, or else lose Dear Reader in a torrent of information. I don't know if you're familiar with the Grain Brain series by Dr. David Perlmutter, but his work, along with many many others, has been pointing to this for a long time. Some years ago Perlmutter was focusing on the problems associated with diabetes and the gut, and a whole constellation of body issues that are associated with our food choices and how they affect the brain/gut connection. I've got an article under development right now which touches on some of these issues. I certainly agree, but would also offer, that you and I have to choose which specific points we're trying to make in any given article without overwhelming the reader. We are only just beginning to understand the loing-term damage done to the biome when we feed ourselves sugar and junk foods early on, leading to poorly performing gut bacteria later in life. Fecal translplants may well be the only answer to that, and that is a field full of possibility....but ONLY if there are still people in the world with a healthy gut biome. That in and of itself is terrifying to consider.